The magnitude of within-group changes in pain ( d = 0.83) and function outcomes (30 second sit-to-stand test d = 1.24 Timed Up-and-Go test d = 0.76) in the intervention group corresponded to medium to very strong effects. Similarly, the intervention group had better improvements in the 30-second sit-to-stand test (between-group difference, 3.4 P < .001) and Timed Up-and-Go test (between-group difference, −1.8 seconds P = .007), as well as the WOMAC subscales for pain (between-group difference, −1.1 P = .02), stiffness (between-group difference, −1.0 P < .001), and physical function (between-group difference, −3.4 P = .02). At the 6-week follow-up, the intervention group showed a greater NRS pain score reduction than the control group (between-group difference, −1.5 P < .001).

There were no significant differences in baseline characteristics between the groups. Results Among a total of 551 participants screened for eligibility, 146 were randomized and 105 were analyzed (mean age, 66.7 years, 71 women), including 48 participants in the intervention group and 57 participants in the control group. Secondary outcomes included 2 physical functioning scores, hamstring and quadriceps muscle strength, the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and quantitative sensory testing. Main Outcomes and Measures The primary outcome was change from baseline to 6 weeks in self-reported pain during the last 7 days, reported on a numerical rating scale (NRS range, 0-10, with 0 indicating no pain and 10, worst pain imaginable), compared between groups. The control group received routine self-management care. For the intervention group, treatment was delivered via a smartphone application. Interventions The intervention and control group conformed to first-line knee osteoarthritis treatment. Participants included individuals aged 45 years or older with a diagnosis of knee osteoarthritis recruited from an existing primary care database or from social media advertisements were invited. Objective To compare the effect of an internet-based treatment for knee osteoarthritis vs routine self-management (ie, usual care).ĭesign, Setting, and Participants This randomized clinical trial was conducted from October 2018 to March 2020.

Importance Osteoarthritis is a prevalent, debilitating, and costly chronic disease for which recommended first-line treatment is underused. Shared Decision Making and Communication.Scientific Discovery and the Future of Medicine.Health Care Economics, Insurance, Payment.Clinical Implications of Basic Neuroscience.Challenges in Clinical Electrocardiography.

Cid episode 1529